There is a constant progress in our understanding of gut-microbiota-liver axis. In this review, we provide the readers with a summary of the recent knowledge related to the field of microbiome and liver disease. For this purpose, we reviewed and selected some of the most distinct studies published between April 2019 and March 2020 with the focus on clinical and translational work related to human data. This overview would allow the readers to obtain the current comprehensive insights in the liver-microbiota field. The work includes the summary of associational studies to obesity, non-alcoholic fatty liver disease, liver cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis and finally hepatocellular carcinoma. The work summarizes also recent interventional studies related to liver disease in particular for the treatment of non-alcoholic fatty liver disease and steatohepatitis.